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salivary large cell carcinoma

Monday 26 June 2017

salivary gland large cell carcinoma

Major salivary gland large-cell undifferentiated carcinoma (LCUC) is rare and has a poor prognosis. Large-cell undifferentiated carcinoma comprised @<@ 1% of all major salivary gland cancers.

In a series (#27545825 #), seventy percent of patients presented with advanced-stage disease. In this series, the incidence of occult nodal disease was 39%. Surgery followed by radiation was the most common treatment. Five-year overall survival was 36%.

The survival analysis demonstrates poorer survival in patients with positive surgical margins. Reported high rates of occult nodal disease also strongly support elective treatment of the neck.

See also

- salivary gland carcinomas / salivary carcinomas
- large cell carcinomas

Paywall references

- Predictors of outcomes in large cell undifferentiated carcinoma of the major salivary glands. Schrank TP, Zhan KY, Lentsch EJ. Laryngoscope. 2017 Feb;127(2):372-376. doi : 10.1002/lary.26136 PMID: 27545825