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ovarian round cell tumors

Thursday 11 May 2017


- ovarian gonadoblastoma

  • Gonadoblastoma has ovarian stroma surrounding nests of germ cells and sex cord stromal cells, with frequent hyalinization and calcification.
  • It is the most frequent tumor found in gonadal dysgenesis, usually a phenotypic female with an XY karyotype and streak gonads.
  • Gonadoblastoma is the most common tumor found in gonadal dysgenesis , most commonly a phenotypic female with XY chromosomes.

- ovarian granulosa cell tumor

  • Granulosa cell tumor has sheets small cells with longitudinal nuclear grooves (“coffee bean nuclei”), and Call-Exner bodies (eosinophilic fluid filled spaces surrounded by granulosa cells).
  • Most tumors cause hyperestrogenism.

- ovarian dysgerminoma

  • Gonadoblastoma can have cells resembling dysgerminoma.
  • Dysgerminoma (seminoma) has fibrous septae infiltrated by lymphocytes, and tumor cells with clear cytoplasm.
  • It tends to arise out of intratubular germ cell neoplasia ( ITGCN ).
  • If syncytiotrophoblast is present, it may also have elevated hCG, but usually not as high as choriocarcinoma.

- ovarian clear cell adenocarcinoma

  • The lesion has large pleomorphic cells with clear cytoplasm and are hobnailed and cuboidal. Mitoses are usually infrequent.
  • The papillary and fibrous cores are hyalinized.
  • These findings are consistent with clear cell adenocarcinoma.
  • It is associated with VHL mutations.
  • Endometriosis is associated with clear cell adenocarcinoma and endometrioid adenocarcinoma.

See also

- ovarian tumors

- round cell tumors