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ovarian spindle cell tumors

Thursday 11 May 2017


- ovarian fibroma

  • Ovarian fibroma has dense benign spindle cells.
  • It is associated with Meigs syndrome (ovarian fibroma, ascites, right pleural effusion), and Gorlin syndrome (basal cell nevus syndrome - basal cell carcinomas, odontogenic keratocyst , PTCH gene, autosomal dominant).

- fibrothecoma

  • Fibrothecoma has features of fibroma and thecoma.

- thecoma

  • Thecoma has lipid vacuolated spindle cells with hyaline plaques.
  • They can produce estrogens and androgens.

- ovarian fibrosarcoma

  • Fibrosarcoma has a herringbone pattern, cellular atypia, and increased mitoses.

- Brenner tumor

  • Brenner tumor contains nests of urothelial type cells with distinct outlines, nuclei with longitudinal grooves (“coffee bean”) and a dense fibroblastic stroma.
  • Brenner tumor can be benign, borderline or malignant depending on the cytologic morphology and behavior.

See also

- ovarian tumors
- spindle cell tumors