Human embryonic stem cells (hESCs) during long-term culture acquire chromosomal changes similar to those occurring in tumorigenesis. This was raised concerns about the progression from hESCs to malignant cells.
See also
culture-adapted hESCs
References
Tumor progression of culture-adapted human embryonic stem cells during long-term culture. Yang S, Lin G, Tan YQ, Zhou D, Deng LY, Cheng DH, Luo SW, Liu TC, Zhou XY, Sun Z, Xiang Y, Chen TJ, Wen JF, Lu GX. Genes Chromosomes Cancer. 2008 Aug;47(8):665-79. PMID: 18470900
