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KRAS-mutated medullary thyroid carcinoma
Monday 17 April 2017
KRAS-associated medullary thyroid carcinoma (wild type RET)
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KRAS-mutated Medullary thyroid carcinoma
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Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology by ThyroSeq v2 next-generation sequencing assay.
Nikiforov YE, Carty SE, Chiosea SI, Coyne C, Duvvuri U, Ferris RL, Gooding WE, Hodak SP, LeBeau SO, Ohori NP, Seethala RR, Tublin ME, Yip L, Nikiforova MN.
Cancer. 2014 Dec 1;120(23):3627-34. doi : 10.1002/cncr.29038
PMID: 25209362 Free
Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.
Boichard A, Croux L, Al Ghuzlan A, Broutin S, Dupuy C, Leboulleux S, Schlumberger M, Bidart JM, Lacroix L.
J Clin Endocrinol Metab. 2012 Oct;97(10):E2031-5. doi : 10.1210/jc.2012-2092
PMID: 22865907 Free
