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Home > E. Pathology by systems > Digestive system > Liver and pancreatobiliary system > Gallbladder > intestinal metaplasia of the gallbladder mucosa

intestinal metaplasia of the gallbladder mucosa

Monday 10 April 2017



- isolated or small clusters of mature goblet cells
- possible argyrophil and argentaffin cells
- less frequently, Paneth cells and gland-like structures similar to colonic crypts.
- possible pseudopyloric glands and superficial gastric-type epithelium

The presence of gut endocrine cells and Paneth cells in the pseudopyloric glands suggests that these glands are also an integral component of intestinal metaplasia of the gallbladder.

Intestinal metaplasia in the gallbladder is strongly associated with expression of caudal-related homeobox transcription factor CDX2.

Cholelithiasis probably induces the appearance of a stem endodermal cell that, in turn, may differentiate into cells with mature intestinal or gastric phenotypes.

See also

- intestinal metaplasia
- gallbladder