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spindle cell ameloblastic carcinoma

Monday 13 March 2017

low-grade spindle cell ameloblastic carcinoma

Definition: Ameloblastic Carcinoma (AC) is uncommon malignant epithelial odontogenic tumour of jaw, with characteristic histologic features and behavior. Clinically, it has aggressive, infiltrative growth pattern with a distinct predilection for mandible. It exhibits histologic features of ameloblastoma and gets dedifferentiated overtime to culminate in carcinoma. Majority of the cases arise denovo (primary) and only few cases arise from a pre-existing ameloblastoma (secondary). Spindle-cell differentiation in ameloblastic carcinoma is rare; Salter described it as a separate entity "low-grade spindle cell ameloblastic carcinoma.

Open references

- A Rare Case Report of Spindle Cell Ameloblastic Carcinoma Involving the Mandible.
Kiresur MA, Kunche A, Ananthaneni A, Bagalad BS, Kuberappa PH.
J Clin Diagn Res. 2017 Jan;11(1):ZD25-ZD27. doi : 10.7860/JCDR/2017/23818.9205
PMID: 28274070 Free