nuclear grooves

See also : coffee bean nuclei

Images

 https://twitter.com/KCampbellMD/status/1083878820850139136

Examples

 papillary thyroid carcinoma (PTC). Grooves & classic "orphan Annie eye" (empty round nuclei)

• https://twitter.com/JMGardnerMD/status/840925854632927232

 Deeply clefted nuclei suspect follicular lymphoma t(14;18)(q32;q21)

• https://twitter.com/patho_arshad/status/863620731258535936

Tumor types

 papillary thyroid carcinoma

• Nuclear grooving is a useful morphologic feature in the diagnosis of papillary carcinoma of the thyroid (PTC) in tissue sections and imprint smears.
• Nuclear grooving, when seen in abundance, can be considered a reliable criterion for the diagnosis of papillary carcinoma in fine needle aspiration cytology of the thyroid.
• The presence of occasional grooves, however, should be regarded as a nonspecific finding.

 Langerahns histiocytosis

• Image: https://twitter.com/neuropathobern/status/663680267706638336

 granulosa cell tumor

• Granulosa cell tumor has sheets of small cells with longitudinal nuclear grooves (“coffee bean nuclei”), and Call-Exner bodies (eosinophilic fluid filled spaces surrounded by granulosa cells). Most tumors cause hyperestrogenism.

See also

 PMID: 2916367

Examples

 papillary thyroid carcinoma
 ovarian benign Brenner tumor

Images

 ovarian benign Brenner tumor

• https://twitter.com/KUSAURAP/status/834264314018041856

See also

 nuclear anomalies