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Monday 30 January 2017


Definition: Protein kinase C-binding protein 1 is an enzyme that in humans is encoded by the ZMYND8 gene.

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.


- RELA-ZMYND8 fusion gene in acute erythroid leukemia (23667654)

Open references

- Fusion of ZMYND8 and RELA genes in acute erythroid leukemia. Panagopoulos I, Micci F, Thorsen J, Haugom L, Buechner J, Kerndrup G, Tierens A, Zeller B, Heim S. PLoS One. 2013 May 7;8(5):e63663. doi : 10.1371/journal.pone.0063663
PMID: 23667654 Free