Home > E. Pathology by systems > Endocrine system > Thyroid > thyroid carcinomas
thyroid carcinomas
Friday 12 December 2003
Digital cases
JRC:2665 : Follicular carcinoma (focal Hurthle cell features), minimally invasive.
JRC:2667 : Poorly differentiated (insular) carcinoma.
JRC:2668 : Thyroid medullary carcinoma, classical type.
JRC:2663 : Thyroid medullary carcinoma, papillary variant.
JRC:2669 : Anaplastic (squamous cell) carcinoma, arising from a preexisting Hurthle cell neoplasm.
JRC:2670 : Thyroid medullary carcinoma, spindle cell variant.
JRC:2672 : Thyroid anaplastic carcinoma, paucicellular variant.
Synopsis
Mainly adults
Classification
well-differentiated carcinomas of the thyroid
- thyroid follicular carcinoma
- thyroid papillary carcinoma
- Hurthle cell thyroid carcinoma
anaplastic carcinoma of the thyroid
According to age
pediatric thyroid carcinomas
- rare but well-reported in childhood
- especially papillary carcinoma
- increased rate with radiation exposure
- tend to present with more advanced disease than adults with lymph node and lung metastases
- have higher recurrence rates but better overall survival
Molecular biology
expression profiling: 12738736, 12707638, 12480920
cDNA libraries: 12480920
CTNNB1 exon 3 mutations in poorly differentiated (25%) and undifferentiated thyroid carcinomas (21.4%) (11238046)
Predisposition
familial thyroid cancers
References
Alsanea O, Clark OH. Familial thyroid cancer. Curr Opin Oncol. 2001 Jan;13(1):44-51. PMID: 11148685