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Friday 13 January 2017


Molecular biology

- EWSR1-ATF1 fusion gene in hyalinizing clear cell carcinoma of salivary gland (HCCC). (21484932)

  • The presence of EWSR1-ATF1 fusion in most HCCCs reliably separates these tumors from its histological mimics.
  • The distinction from mucoepidermoid carcinoma (MEC) is particularly important, as conventional MEC grading schemes overgrade these indolent HCCCs, potentially impacting on treatment.

See also : ATF1 and EWSR1