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C11orf95-MKL2

Friday 13 January 2017

Pathology

- C11orf95-MKL2 fusion gene in chondroid lipoma ( MLK2 )

  • Chondroid lipoma occurs most often in the limbs as a subcutaneous lesion in adults and is characterized by an admixture of chondroblast-like cells, bland-looking lipoblasts and mature adipocytes in varying proportions.
  • Although these lesions may be mistaken for sarcoma by the unwary, they appear to be entirely benign with virtually no tendency for local recurrence.

Cytogenetics

- t(11;16)(q13;p12-13) ( 11q13 and 16p12-13 )

Open references

- C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA. Genes Chromosomes Cancer. 2010 Sep;49(9):810-8. doi : 10.1002/gcc.20788
PMID: 20607705 Free

Paywall references

- Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases. Flucke U, Tops BB, de Saint Aubain Somerhausen N, Bras J, Creytens DH, K├╝sters B, Groenen PJ, Verdijk MA, Suurmeijer AJ, Mentzel T. Histopathology. 2013 May;62(6):925-30. doi : 10.1111/his.12100
PMID: 23672313

- The evolving classification of soft tissue tumours: an update based on the new WHO classification. Fletcher CD. Histopathology. 2006 Jan;48(1):3-12. PMID: 16359532