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low-grade cribriform cystadenocarcinoma

Wednesday 11 January 2017


Definition: Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described rare tumor of salivary gland which exhibits clinically indolent behavior.

This tumor predominantly consists of intraductal components and frequently exhibits papillary-cystic or cribriform proliferation pattern.


Immunohistochemically, the luminal tumor cells show diffuse expression of CK and S100.

p63 and smooth muscle actin display a continuous rim of myoepithelial cells around all tumor islets; no myoepithelial cells were admixed with the luminal cells.

Differential diagnosis

Considering the histological features of LGCCC, it should be distinguished with :
- papillocystic variant of acinic cell carcinoma ,
- conventional salivary duct carcinoma ,
- cystadenocarcinoma ,
- polymorphous low-grade adenocarcinoma,
- carcinoma ex pleomorphic adenoma
- mammary analogue secretory carcinoma MASC).

Open references

- Low-grade cribriform cystadenocarcinoma of salivary glands: report of two cases. 2013. doi : 10.1186/1746-1596-8-28