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molecular pathology of liquid-based cytology
Sunday 16 October 2016
LBC may have disadvantages in long-term DNA preservation because of its accelerated DNA degradation compared with alcohol-fixed CS. Using primers to amplify shorter size fragments might be helpful in mitigating loss of signal due to DNA degradation in LBC.
References
DNA degradation in liquid-based cytology and its comparison with conventional smear. Kim WY, Oh SY, Kim H, Hwang TS. Diagn Cytopathol. 2016 May;44(5):450-8. doi : 10.1002/dc.23441
PMID: 26801351
