keratinocytes

WP

Definition : A keratinocyte is the predominant cell type in the epidermis, the outermost layer of the skin, constituting 90% of the cells found there. Those keratinocytes found in the basal layer (stratum basale) of the skin are sometimes referred to as "basal cells" or "basal keratinocytes".

Pathology

 vacuolated keratinocytes
 dysplastic keratinocytes

• tumoral keratinocytes

 mitotic keratinocytes

• https://twitter.com/DrAldehyde/status/1295867333580410880

 necrotic keratinocytes / dying keratinocytes

• example : cutaneous GVHD
• example : porokeratosis of Mibelli
• example : acute generalized exanthematous pustulosis (AGEP)

 acantholytic keratinocytes

See also

 epidermal basal cells
 corneocytes
 keratin

Videos

 Keratocytes, found on the scales of fish, are specialized for very rapid motility in order to heal scratches."

@<@object width="425" height="350">@<@param name="movie" value="http://www.youtube.com/v/-3SRRwVYAt4">@<@/param>@<@param name="wmode" value="transparent">@<@/param>@<@embed src="http://www.youtube.com/v/-3SRRwVYAt4" type="application/x-shockwave-flash" wmode="transparent" width="425" height="350">@<@/embed>@<@/object>

Ref.: Molecular Biology of the Cell, 4th Edition, by Alerts, Johnson, Lewis. Raff, Roberts, Walter.

References

 Nickoloff BJ. Keratinocytes regain momentum as instigators of cutaneous inflammation. Trends Mol Med. 2006 Mar;12(3):102-6. PMID: 16443394

 Dhitavat J, Fairclough RJ, Hovnanian A, Burge SM. Calcium pumps and keratinocytes: lessons from Darier’s disease and Hailey-Hailey disease. Br J Dermatol. 2004 May;150(5):821-8. PMID: 15149492

 Werner S, Smola H. Paracrine regulation of keratinocyte proliferation and differentiation. Trends Cell Biol. 2001 Apr;11(4):143-6. PMID: 11306276