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lymphocytic esophagitis

Wednesday 28 September 2016

Definition: Lymphocytic esophagitis is an histologic phenotype of chronic esophagitis.

Lymphocytic esophagitis is characterized by high numbers of intraepithelial lymphocytes (IELs) gathered mainly around peripapillary fields and by none (n = 12) to occasional (n = 8) CD15+ intraepithelial granulocytes.

IELs expressed CD3, CD4 (42%), CD8 (36%), and granzyme B (0.2%), whereas T-cell intracytoplasmic antigen (TIA) 1 was not expressed.

See also

- esophagitis

IOpen references

- Lymphocytic esophagitis: a histologic subset of chronic esophagitis.
Rubio CA, Sjödahl K, Lagergren J.
Am J Clin Pathol. 2006 Mar;125(3):432-7.
PMID: 16613348 (Free)

Paywall references

- Lymphocytic Esophagitis in Nonachalasia Primary Esophageal Motility Disorders: Improved Criteria, Prevalence, Strength of Association, and Natural History. Putra J, Muller KE, Hussain ZH, Parker S, Gabbard S, Brickley EB, Lacy BE, Rothstein R, Lisovsky M. Am J Surg Pathol. 2016 Dec;40(12):1679-1685.
PMID: 27526295