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HEY1
Saturday 20 August 2016
Definition: Hairy/enhancer of split-related proteins (HEYs ), such as HEY1, are basic helix-loop-helix transcription factors (bHLH transcription factors) implicated in cell fate decision and boundary formation.
HEYs genes are direct transcriptional targets of the Notch signaling pathway in Drosophila and vertebrates.
Pathology
HEY1-NCOA2 Gene Fusion in mesenchymal chondrosarcoma (27544802)
- between HEY1 and NCOA2
Open references
Chromosome aberrations and HEY1-NCOA2 fusion gene in a mesenchymal chondrosarcoma. Panagopoulos I, Gorunova L, Bjerkehagen B, Boye K, Heim S.
Oncol Rep. 2014 Jul;32(1):40-4. doi : 10.3892/or.2014.3180
PMID: 24839999
HEYS members - HEYs
| HEY1 | HEY2 |
See also
HEYL
Notch signaling pathway
Open references
Notch signaling in prostate cancer: a moving target.
Carvalho FL, Simons BW, Eberhart CG, Berman DM.
Prostate. 2014 Jun;74(9):933-45. doi : 10.1002/pros.22811
PMID: 24737393 Free
Notch signaling in cardiac development.
Niessen K, Karsan A.
Circ Res. 2008 May 23;102(10):1169-81. doi : 10.1161/CIRCRESAHA.108.174318
PMID: 18497317 Free
