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ruptured crypt granuloma
Tuesday 9 August 2016
colonic crypt rupture granuloma
Definition: Crypt-associated giant cells and granulomas can occur in ulcerative colitis and in themselves are unreliable features for the discrimination between Crohn’s disease and ulcerative colitis.
Isolated giant cells and well-defined epithelioid granulomas distant from crypts do not, as a rule, occur in ulcerative colitis, and hence their presence in a colonoscopic biopsy showing features of chronic inflammatory bowel disease is a strong pointer towards the diagnosis of Crohn’s disease.
Examples
ulcerative colitis : ruptured crypt granuloma : mucous extravasation after cryptic dysruption
- https://twitter.com/DraEosina/status/7629614344184832004
- https://twitter.com/GIPathologyURMC/status/879401801933615105
See also
colonic granuloma
colonic anomalies
grnaulomas
Paywall references
Granulomatous ulcerative colitis: a re-appraisal of the mucosal granuloma in the distinction of Crohn’s disease from ulcerative colitis.
Mahadeva U, Martin JP, Patel NK, Price AB.
Histopathology. 2002 Jul;41(1):50-5.
PMID: 12121237
