Humpath.com - Human pathology

Home > A. Molecular pathology > H3F3A

H3F3A

Monday 8 August 2016

H3.3; H3; H3F3A

See also : oncohistones

Images

- Histone3.3G34W IHC identifies the mutation driving 90% of bone giant cell tumors

Molecular biology

- H3F3A-K27M mutation in H3F3A / mutated K27M-H3.3 in glial tumors

  • K27M mutation in H3F3A in ganglioglioma grade I with spontaneous malignant
    transformation
  • BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology. (26487540)
  • Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. (26399631)
  • ATRX immunostaining predicts IDH and H3F3A status in gliomas. (27311324)

- Mutation Analysis of H3F3A and H3F3B is a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma. (26457357)

  • H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone. (28505000)
  • H3F3A mutation in giant cell tumour of the bone is detected by immunohistochemistry using a monoclonal antibody against the G34W mutated site of the histone H3.3 variant. (28211081)
  • Histone3.3G34W IHC identifies the mutation driving 90% of bone giant cell tumors

- chondroblastoma

  • The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. (26844533)

See also

- histone H3 pathway

  • histone H3 oncogenic pathway

Open References

- Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation. Orillac C, Thomas C, Dastagirzada Y, Hidalgo ET, Golfinos JG, Zagzag D, Wisoff JH, Karajannis MA, Snuderl M. Acta Neuropathol Commun. 2016 Aug 12;4(1):84. doi : 10.1186/s40478-016-0361-0
PMID: 27519587 Free

- ATRX immunostaining predicts IDH and H3F3A status in gliomas. Ebrahimi A, Skardelly M, Bonzheim I, Ott I, Mühleisen H, Eckert F, Tabatabai G, Schittenhelm J.
Acta Neuropathol Commun. 2016 Jun 16;4(1):60. doi : 10.1186/s40478-016-0331-6 PMID: 27311324 Free

- Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.
Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pagès M, Taylor KR, Saulnier P, Lacroix L, Mackay A, Jones C, Sainte-Rose C, Blauwblomme T, Andreiuolo F, Puget S, Grill J, Varlet P, Debily MA.
Acta Neuropathol. 2015 Dec;130(6):815-27. doi : 10.1007/s00401-015-1478-0
PMID: 26399631 Free

Paywall references

- The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma.
Amary MF, Berisha F, Mozela R, Gibbons R, Guttridge A, O’Donnell P, Baumhoer D, Tirabosco R, Flanagan AM.
Histopathology. 2016 Jul;69(1):121-7. doi : 10.1111/his.12945
PMID: 26844533