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Home > A. Molecular pathology > Fusion genes > DNAJB1-PRKACA


Wednesday 6 July 2016

Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including cytokeratin 7 and CD68 co-expression.

Recently, fibrolamellar carcinomas were found to harbor a characteristic somatic gene fusion, DNAJB1 - PRKACA.

FISH for the PRKACA rearrangement is a clinically useful tool to confirm the diagnosis of fibrolamellar carcinoma, with high sensitivity and specificity.

See also


Open references

- Hepatocellular Carcinoma, Fibrolamellar Variant: Diagnostic Pathologic Criteria and Molecular Pathology Update. A Primer. 2016.

- Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma. 2015. (24578576)