Home > A. Molecular pathology > Fusion genes > DNAJB1-PRKACA
DNAJB1-PRKACA
Wednesday 6 July 2016
Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including cytokeratin 7 and CD68 co-expression.
Recently, fibrolamellar carcinomas were found to harbor a characteristic somatic gene fusion, DNAJB1 - PRKACA.
FISH for the PRKACA rearrangement is a clinically useful tool to confirm the diagnosis of fibrolamellar carcinoma, with high sensitivity and specificity.
See also
DNAJB1
PRKACA
Open references
Hepatocellular Carcinoma, Fibrolamellar Variant: Diagnostic Pathologic Criteria and Molecular Pathology Update. A Primer. 2016. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808818/
Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma. 2015. (24578576) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286414/
