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primary lingual colonic-type adenocarcinoma

Thursday 30 June 2016

primary colonic-type adenocarcinoma of the tongue

Primary colonic-type adenocarcinoma involving the tongue (CTAT) is exquisitely rare.

The mass consists of invasive adenocarcinoma associated with “dirty necrosis”, akin to the phenotype seen in colorectal adenocarcinoma.

By immunohistochemistry, the tumor cells are positive for AE1/3+ , CDX2+ , CK20+ , SATB2+ and beta-catenin+ (CTNB1+ ).

A metastatic disease muste be excluded before rendering a diagnosis of CTAT.

Open references

- Colonic-type adenocarcinoma of the base of the tongue: a case report of a rare neoplasm. Slova D, Paniz Mondolfi A, Moisini I, Levi G, Urken M, Zevallos J, Mansoor S, Khorsandi A, Bloch D, Vidhun R, Wenig B. Head Neck Pathol. 2012 Jun;6(2):250-4. doi : 10.1007/s12105-011-0301-z PMID: 21948243 (Free)

- Primary colonic-type adenocarcinoma of the base of the tongue: a previously unreported phenotype. Bell D, Kupferman ME, Williams MD, Rashid A, El-Naggar AK. Hum Pathol. 2009 Dec;40(12):1798-802. doi : 10.1016/j.humpath.2009.01.028 PMID: 19695679 (Free)