Home > E. Pathology by systems > Urinary system > invasive urothelial carcinoma
invasive urothelial carcinoma
Friday 17 June 2016
urothelial carcinomas
WP | PO |
Images
pT1 : lamina propria invasion / Invasive urothelial carcinoma
pT2 : Muscularis Propria Invasion
- http://www.webpathology.com/image.asp?case=56&n=12
- https://twitter.com/Andres_Matoso/status/859870022042353665
- https://twitter.com/Rahimah_MD/status/1445691281007464448
Urothelial Carcinoma - Vascular Invasion
Invasive urothelial carcinoma invading the kidney
patterns of invasive urothelial carcinoma
IHC
positive expression
- CK7 ,
- CK20 (50%),
- HMW keratin (80%),
- uroplakin (40-60%, but highly specific),
- thrombomodulin (Am J Surg Pathol 2003;27:1),
- variable p63
- Also MUC1 , CEA , p53 , GATA3 , S100
- Variable CA125 (Int J Biol Markers 1994;9:224),
- variable HER2
- CD31 , CD34 , and podoplanin (D2-40) are useful to distinguish true lymphatic invasion from retraction artifact, particularly in micropapillary variant
Note: keratin may stain non-tumor cells in repeat biopsy cases (Am J Surg Pathol 2007;31:390)
Note: CK20 staining pattern in primary tumor is replicated in metastases (Arch Pathol Lab Med 2001;125:921)
negative expression
- Prostatic markers PSA , P501S , PSMA , NKX3.1 and pPSA (Am J Surg Pathol 2007;31:1246)
- WT1 ,
- MUC2 ,
- MUC5AC (Am J Clin Pathol 2004;122:61),
- HPV ,
- Leu7/CD57
See also
urothelial carcinoma
-
non-invasive urothelial carcinoma
- non-invasive papillary urothelial carcinoma
- non-invasive flat urothelial carcinoma : urothelial carcinoma in situ