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invasive urothelial carcinoma

Friday 17 June 2016

urothelial carcinomas

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Images

- pT1 : lamina propria invasion / Invasive urothelial carcinoma

- pT2 : Muscularis Propria Invasion

- Urothelial Carcinoma - Vascular Invasion

- Invasive urothelial carcinoma invading the kidney

- patterns of invasive urothelial carcinoma

IHC

- positive expression

  • CK7 ,
  • CK20 (50%),
  • HMW keratin (80%),
  • uroplakin (40-60%, but highly specific),
  • thrombomodulin (Am J Surg Pathol 2003;27:1),
  • variable p63
  • Also MUC1 , CEA , p53 , GATA3 , S100
  • Variable CA125 (Int J Biol Markers 1994;9:224),
  • variable HER2
  • CD31 , CD34 , and podoplanin (D2-40) are useful to distinguish true lymphatic invasion from retraction artifact, particularly in micropapillary variant

Note: keratin may stain non-tumor cells in repeat biopsy cases (Am J Surg Pathol 2007;31:390)

Note: CK20 staining pattern in primary tumor is replicated in metastases (Arch Pathol Lab Med 2001;125:921)

- negative expression

  • Prostatic markers PSA , P501S , PSMA , NKX3.1 and pPSA (Am J Surg Pathol 2007;31:1246)
  • WT1 ,
  • MUC2 ,
  • MUC5AC (Am J Clin Pathol 2004;122:61),
  • HPV ,
  • Leu7/CD57

See also

- urothelial carcinoma