- Human pathology

Home > E. Pathology by systems > Urinary system > micropapillary urothelial carcinoma

micropapillary urothelial carcinoma

Tuesday 31 May 2016

Micropapillary urothelial carcinoma of the bladder

Definition : Invasive micropapillary carcinoma is the name given to a distinctive pattern of carcinoma characterized by cleft formation around neoplastic cell

Tumors with this morphology, even when focal in otherwise conventional carcinoma, are characterized by a high degree of lymphotropism.

Electron microscopy examination in a handful of invasive micropapillary carcinoma cases demonstrated an unexpected secretory activity in the stroma-facing surface of the tumor cells suggesting a reversal in cell polarity in this particular type of tumor.


- Micropapillary urothelial carcinoma of the bladder

- MUC1 expression


- aggressive histological subtype of urothelial carcinoma / UC
- multiple small clusters of tumour cells in same lacuna
- frequent overexpression of Her-2 / HER2

See also

- urothelial carcinomas
- micropapillary carcinomas


- Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. 2017.

- E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma. Lim MG, Adsay NV, Grignon DJ, Osunkoya AO. Mod Pathol. 2010 Sep 3. PMID: 20818341