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micropapillary urothelial carcinoma

Tuesday 31 May 2016

Micropapillary urothelial carcinoma of the bladder

Invasive micropapillary carcinoma is the name given to a distinctive pattern of carcinoma characterized by cleft formation around neoplastic cell
clusters.

Tumors with this morphology, even when focal in otherwise conventional carcinoma, are characterized by a high degree of lymphotropism.

Electron microscopy examination in a handful of invasive micropapillary carcinoma cases demonstrated an unexpected secretory activity in the stroma-facing surface of the tumor cells suggesting a reversal in cell polarity in this particular type of tumor.

Images

- Micropapillary urothelial carcinoma of the bladder

- MUC1 expression

See also

- urothelial carcinomas

References

- Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. 2017. https://www.nature.com/modpathol/journal/v17/n9/pdf/3800166a.pdf

- E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma. Lim MG, Adsay NV, Grignon DJ, Osunkoya AO. Mod Pathol. 2010 Sep 3. PMID: 20818341