nuclear pseudoinclusions

Definition: Nuclear pseudoinclusions represent invaginations of cytoplasm into the nucleus.

Images

Intranuclear cytoplasmic inclusions

• https://twitter.com/a_sleeping_dog/status/766154834185641984

 Intranuclear cytoplasmic inclusions in paraganglioma

• https://twitter.com/cjvand/status/1255687089141800961

 Dutcher bodies (nuclear pseudo-inclusions) in plasma cell myeloma

• https://twitter.com/HemepathUAMS/status/819908698944507908

They are delimited by the nuclear membrane. Although not totally specific, they are particularly common in papillary thyroid carcinoma, meningioma, and usual ductal hyperplasia of the breast and hence may aid in the diagnosis of these entities.

Nuclear pseudo-pseudoinclusions, which are artefactual bubbles in the nuclei that mimic nuclear pseudoinclusions or clear nuclei, can lead to misdiagnosis of follicular adenoma or hyperplastic nodule as papillary thyroid carcinoma.

See also

 cellular inclusions

• nuclear inclusions
• cytoplasmic inclusions

 microscopical anomalies

• cellular anomalies
  • nuclear anomalies

References

 Nuclear inclusions and pseudoinclusions: friends or foes of the surgical pathologist? Ip YT, Dias Filho MA, Chan JK. Int J Surg Pathol. 2010 Dec;18(6):465-81. doi : 10.1177/1066896910385342 PMID: 21081532