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fibroblasts

Thursday 27 November 2003

Adj. fibroblastic

Fibroblasts are a type of cell found in all tissues of the body. They help to maintain the structural integrity of connective tissues by secreting the protein collagen and other components of the material that comprises the extracellular matrix, which provides support for neighbouring cells.

Features

- CD34+ fibroblasts
- plasticity of fibroblasts

  • phenotypic plasticity of fibroblasts

Pathology

- inflammation

  • Despite their crucial role in maintaining a healthy tissue architecture, it is becoming increasingly clear that fibroblasts can also contribute to inflammation and tissue injury in a variety of autoimmune diseases.
  • For example, rheumatoid arthritis is a condition characterized by persistent inflammation, bone erosion and the destruction of cartilage in the joints. Croft et al. report evidence indicating that the progression of rheumatoid arthritis is driven by two populations of fibroblast that have distinct gene-expression profiles. doi : 10.1038/d41586-019-01594-9

- fibroblastic sarcomas

References

- Neumann E, Gay RE, Gay S, Muller-Ladner U. Functional genomics of fibroblasts. Curr Opin Rheumatol. 2004 May;16(3):238-45. PMID: 15103251

- Grinnell F. Fibroblast biology in three-dimensional collagen matrices. Trends Cell Biol. 2003 May;13(5):264-9. PMID: 12742170

- Grinnell F. Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading. Trends Cell Biol. 2000 Sep;10(9):362-5. PMID: 10932093