eosinophilic, solid, and cystic renal cell carcinoma

Definition: This renal neoplasm characterized by eosinophilic cytoplasm and solid and cystic growth has been reported in patients with tuberous sclerosis complex (TSC).

Images

 Wikimedia: eosinophilic, solid and cystic renal cell carcinoma

Although similar to this subset of renal cell carcinomas (RCCs) seen in TSC, it has been proposed that sporadic "eosinophilic, solid, and cystic RCC," (ESC RCC) as a specific entity.

It occurs predominantly in female individuals and is characterized by distinct morphologic features, predominant CK20-positive/CK7-negative immunophenotype, and indolent behavior.

CGH

 gains

• 7p21.2-7q36.2
• 16p13.3-16q23.1

 losses

• Xp11.21

References

 Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. Trpkov K, Hes O, Bonert M, Lopez JI, Bonsib SM, Nesi G, Comperat E, Sibony M, Berney DM, Martinek P, Bulimbasic S, Suster S, Sangoi A, Yilmaz A, Higgins JP, Zhou M, Gill AJ, Przybycin CG, Magi-Galluzzi C, McKenney JK. Am J Surg Pathol. 2016 Jan;40(1):60-71. doi : 10.1097/PAS.0000000000000508 PMID: 26414221