Home > E. Pathology by systems > Reproductive system > Female genital system > Breast > atypical hyperplasias
atypical hyperplasias
Monday 23 November 2015
atypical epithelial hyperplasia of the breast; mammary atypical hyperplasias
Types
atypical ductal hyperplasia (ADH)
columnar cell change with atypia
atypical lobular hyperplasia (ALH)
Types
atypical ductal hyperplasia (ADH)
- ADH is important because it carries a 4-5 times relative risk of breast cancer at 10-15 yrs post biopsy.
- Usually solitary
- Confined to a single lobular unit
- Seldom larger than 3mm
- At least focally a uniform cell population and architectural features of low grade DCIS.
- Cribriform, micropapillary or solid growth pattern
- Secondary lumina some of which are rigid while others are tapering
- Evenly spaced cells with hyperchromatic nuclei
- monotonous population of epithelial cells showing rigid structure across ducts and low grade cytology.
- Luminal microcalcifications can be present.
- possible mucocele-like lesion
columnar cell change with atypia
- Columnar cell change with atypia
atypical lobular hyperplasia (ALH)
Links
