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ovarian surface epithelium

Friday 6 November 2015

Pathology

- Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer deaths among women in the United States, but its pathogenesis is poorly understood.

  • Some epithelial cancers are known to occur in transitional zones between two types of epithelium, whereas others have been shown to originate in epithelial tissue stem cells.
  • The stem cell niche of the ovarian surface epithelium (OSE), which is ruptured and regenerates during ovulation, has not yet been defined unequivocally.
  • A study supports experimentally the idea that susceptibility of transitional zones to malignant transformation may be explained by the presence of stem cell niches in those areas. (23467088)
  • Identification of a stem cell niche for the OSE may have important implications for understanding EOC pathogenesis. (23467088)

References

- Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche. Flesken-Nikitin A, Hwang CI, Cheng CY, Michurina TV, Enikolopov G, Nikitin AY. Nature. 2013 Mar 14;495(7440):241-5. doi : 10.1038/nature11979 PMID: 23467088