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CDKN2D

Friday 13 November 2015

p19Ink4d

WP

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

The protein encoded by this gene CDKN2D is a member of the INK4 family of cyclin-dependent kinase inhibitors (INK4s). This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression.

The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase.

The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

Note, this protein should not be confused with p19-ARF (mouse) or the human equivalent p14-ARF, which are alternative products of the CDKN2A gene.

Pathology

- p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation. (24687853)

Open reference

- p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation. Bai F, Chan HL, Smith MD, Kiyokawa H, Pei XH. Mol Cell Biol. 2014 Jun;34(12):2121-34. doi : 10.1128/MCB.01363-13 PMID: 24687853 (Free)