MED15

WKP

Mediator of RNA polymerase II transcription subunit 15 (MED15) is a protein encoded by the MED15 gene.

MED15 is part of the multiprotein Mediator complex which presents an integrative hub for transcriptional regulation.

Pathology

MED15 is known to be deregulated in several malignancies, such as prostate cancer and bladder cancer role, whereas the role of the Mediator complex in TGCT has not been investigated so far. Aim of the study was to investigate the implication of MED15 in TGCT development and its stratification into histological subtypes.

 testicular germ cell tumor

• MED15 is differentially expressed in tumor-free testis and TGCT.
• While MED15 is absent or low in tumor-free testis and SEM, NSGCT highly express MED15, hinting at the diagnostic potential of this marker to distinguish between SEM and NSGCT.
• Further, the precursor lesion IGCNU showed increased nuclear MED15 expression in the preinvasive precursor cells, which may provide diagnostic value to distinguish between benign and pre-malignant testicular specimen, and may indicate a role for MED15 in carcinogenesis in TGCT.

Open references

 Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors. Klümper N, Syring I, Offermann A, Shaikhibrahim Z, Vogel W, Müller SC, Ellinger J, Strauß A, Radzun HJ, Ströbel P, Brägelmann J, Perner S, Bremmer F. Diagn Pathol. 2015 Sep 17;10(1):165. doi : 10.1186/s13000-015-0398-6 PMID: 26377566 (Free)