TRPS1

WKP

Zinc finger transcription factor Trps1 is a protein that in humans is encoded by the TRPS1 gene. This gene encodes a GATA-like transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein.

Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity.

Pathology

 gerline mutations

• Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III (also known as the Langer-Giedion syndrome).

 osteosarcoma

• Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma. (26377811 )

Open references

 Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma. Li Z, Jia M, Wu X, Cui J, Pan A, Li L. Diagn Pathol. 2015 Sep 17;10(1):167. doi : 10.1186/s13000-015-0401-2 PMID: 26377811