CPEB4

Cytoplasmic polyadenylation elements (CPEs) are located in the 3-prime UTRs of hundreds of mRNAs involved in cell proliferation, chromosome segregation, and cell differentiation. CPEs function as docking sites for CPE-binding proteins (CPEBs), which can either repress or activate mRNA translation.

CPEB4 activates mRNA translation by adding poly(A) tails to target mRNAs (Ortiz-Zapater et al., 2012).

Pathology

 lung cancer

• The microRNA-1246 promotes metastasis in non-small cell lung cancer by targeting cytoplasmic polyadenylation element-binding protein 4. (26209100)
• miR-1246 may promote cell metastasis by targeting CPEB4.
• Meanwhile, the level of CPEB4 could be used as a potential marker in NSCLC patients.

See also

 CPEBs