CPEBs

Definition: CPEs function as docking sites for CPE-binding proteins (CPEBs), which can either repress or activate mRNA translation. CPEB4 activates mRNA translation by adding poly(A) tails to target mRNAs (Ortiz-Zapater et al., 2012).

Cytoplasmic polyadenylation elements (CPEs) are located in the 3-prime UTRs of hundreds of mRNAs involved in cell proliferation , chromosome segregation , and cell differentiation.

The cytoplasmic polyadenylation element-binding (CPEB) proteins regulate pre-mRNA processing and translation of CPE-containing mRNAs in early embryonic development and synaptic activity.

Members

 CPEB1 , CPEB2 , CPEB3,
 CPEB4

• CPEB4 activates mRNA translation by adding poly(A) tails to target mRNAs (Ortiz-Zapater et al., 2012).