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ITPKA

MIM.147521

Monday 14 September 2015

WKP

Inositol-trisphosphate 3-kinase A (ITPKA) is an enzyme that in humans is encoded by the ITPKA gene.It regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4.

The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. ITPKA and ITPKB are 68% identical in the C-terminus region.

Pathology

- Inositol-1,4,5-trisphosphate-3-kinase-A (ITPKA) has been found to be implicated in the tumor progression of various cancers.

- ITPKA expression is a novel prognostic factor in hepatocellular carcinoma. (26249031)

  • ITPKA expression was significantly up-regulated in HCC and could serve as a potential novel prognostic biomarker for HCC patients after surgery. (26249031)

Open references

- ITPKA expression is a novel prognostic factor in hepatocellular carcinoma. Li J, Zhu YH, Huang P, Zhang B, Sun J, Guan XY. Diagn Pathol. 2015 Aug 7;10:136. doi : 10.1186/s13000-015-0374-1 PMID: 26249031 (Free)