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NUT-associated carcinomas
Wednesday 9 September 2015
Images
NUT carcinoma must always be considered when there is abrupt keratinization.
Genetics
These tumors are diffusely positive for p63 and NUT expression and are partially positive for various cytokeratins.
Reverse transcription polymerase chain reaction analysis and subsequent direct sequencing reveal that the bromodomain-containing protein 4-NUT chimeric gene is present in tumor tissue of both patients, leading to a diagnosis of NMC.
Types
NUT-associated midline carcinoma
NUT-associated pulmonary carcinoma
Open References
NUT expression in primary lung tumours. Lund-Iversen M, Grøholt KK, Helland Å, Borgen E, Brustugun OT. Diagn Pathol. 2015 Sep 5;10(1):156. doi : 10.1186/s13000-015-0395-9 PMID: 26341600 (Free)
References
NUT Midline Carcinoma: Report of 2 Cases Suggestive of Pulmonary Origin. Tanaka M, Kato K, Gomi K, Yoshida M, Niwa T, Aida N, Kigasawa H, Ohama Y, Tanaka Y. Am J Surg Pathol. 2012 Mar;36(3):381-8. PMID: 22301500