Humpath.com - Human pathology

Home > G. Tumoral pathology > NUT-associated carcinomas

NUT-associated carcinomas

Wednesday 9 September 2015

Images

-  NUT carcinoma must always be considered when there is abrupt keratinization.

Genetics

These tumors are diffusely positive for p63 and NUT expression and are partially positive for various cytokeratins.

Reverse transcription polymerase chain reaction analysis and subsequent direct sequencing reveal that the bromodomain-containing protein 4-NUT chimeric gene is present in tumor tissue of both patients, leading to a diagnosis of NMC.

Types

- NUT-associated midline carcinoma
- NUT-associated pulmonary carcinoma

Open References

- NUT expression in primary lung tumours. Lund-Iversen M, Grøholt KK, Helland Å, Borgen E, Brustugun OT. Diagn Pathol. 2015 Sep 5;10(1):156. doi : 10.1186/s13000-015-0395-9 PMID: 26341600 (Free)

References

- NUT Midline Carcinoma: Report of 2 Cases Suggestive of Pulmonary Origin. Tanaka M, Kato K, Gomi K, Yoshida M, Niwa T, Aida N, Kigasawa H, Ohama Y, Tanaka Y. Am J Surg Pathol. 2012 Mar;36(3):381-8. PMID: 22301500