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ovarian high-grade serous carcinoma
Wednesday 8 July 2015
OHGSC; high-grade ovarian serous carcinoma : high-grade serous carcinoma of the ovary
Images
Metastatic emboli from high grade serous carcinoma
High-grade serous carcinoma in peritoneal fluid
See also
ovarian serous carcinoma
Molecular pathology
- Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma. (25216223)
- Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma. (25216223)
- ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches. (22144423)
- In mice, stem cells at the ovarian hilum have been shown to express the stem cell marker, aldehyde dehydrogenase isoform 1A1 (ALDH1A1), and are prone to malignant transformation.
- The Cancer Genome Atlas revealed downregulation of ALDH1A1 transcripts in high-grade serous carcinoma relative to normal tubal epithelium, and no association between ALDH1A1 expression levels and overall survival.
- Some results do not support ALDH1A1 as a specific marker of stem cells in human fallopian tube and demonstrate that its loss of expression is an early event in the development of high-grade serous carcinoma. (25216223)
Open references
Loss of ALDH1A1 expression is an early event in the pathogenesis of ovarian high-grade serous carcinoma. Chui MH, Wang Y, Wu RC, Seidman J, Kurman RJ, Wang TL, Shih IeM. Mod Pathol. 2015 Mar;28(3):437-45. doi : 10.1038/modpathol.2014.89 PMID: 25216223
