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CDH17

Friday 27 March 2015

cadherin-17; cadherin 17;

Cadherin 17 (CDH17) is expressed primarily in the normal intestine and digestive tract tumors and has not been detected in tumors from other sites including the kidney.

Expression in tumors

- metanephric adenoma

  • Metanephric adenoma (MA) is a rare benign renal neoplasm that shares morphologic and immunophenotypic overlap with epithelial-predominant Wilms tumor (e-WT) and with the solid variant of papillary renal cell carcinoma (s-PRCC).
  • CDH17 is a sensitive (81%) and highly specific (100%) marker for MA and should be considered in the immunohistochemistry panel for distinguishing MA from its mimics.

References

- Cadherin 17 is a sensitive and specific marker for metanephric adenoma. Yakirevich E, Magi-Galluzzi C, Grada Z, Lu S, Resnick MB, Mangray S. Am J Surg Pathol. 2015 Apr;39(4):479-86. doi : 10.1097/PAS.0000000000000401 PMID: 25768256