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CDH17
Friday 27 March 2015
cadherin-17; cadherin 17;
Cadherin 17 (CDH17) is expressed primarily in the normal intestine and digestive tract tumors and has not been detected in tumors from other sites including the kidney.
Expression in tumors
metanephric adenoma
- Metanephric adenoma (MA) is a rare benign renal neoplasm that shares morphologic and immunophenotypic overlap with epithelial-predominant Wilms tumor (e-WT) and with the solid variant of papillary renal cell carcinoma (s-PRCC).
- CDH17 is a sensitive (81%) and highly specific (100%) marker for MA and should be considered in the immunohistochemistry panel for distinguishing MA from its mimics.
References
Cadherin 17 is a sensitive and specific marker for metanephric adenoma. Yakirevich E, Magi-Galluzzi C, Grada Z, Lu S, Resnick MB, Mangray S. Am J Surg Pathol. 2015 Apr;39(4):479-86. doi : 10.1097/PAS.0000000000000401 PMID: 25768256
