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primary hepatic tumors with myxoid change

Friday 27 February 2015

Mucin production in primary liver neoplasms is typically interpreted as evidence for biliary differentiation. However, it has been observed benign and malignant liver tumors that have abundant extracellular myxoid/mucinous material, yet have only evidence of hepatocellular differentiation.

Extracellular myxoid/mucinous material in isolation should not be interpreted as cholangiocarcinoma. Furthermore, the unique morphology, the clinical characteristics, and the immunophenotype results suggest that myxoid hepatic adenomas and hepatocellular carcinoma may be unique tumor variants.


- Primary hepatic tumors with myxoid change: morphologically unique hepatic adenomas and hepatocellular carcinomas. Salaria SN, Graham RP, Aishima S, Mounajjed T, Yeh MM, Torbenson MS. Am J Surg Pathol. 2015 Mar;39(3):318-24. doi : 10.1097/PAS.0000000000000382 PMID: 25602798