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nodal EBV-associated cytotoxic T-cell lymphoma

Wednesday 25 February 2015

EBV-associated cytotoxic T-cell lymphoma of lymph nodes; nodal EBV-positive cytotoxic T-cell lymphoma; nodal EBV cytotoxic T-cell lymphoma


- apperance (25634749).

  • centroblastoid appearance (56%) (lower incidence in ENKTL :15%).
  • pleomorphic appearance ( 23%) (ENKTL : 67%).

- T-cell lineage (85%) on the basis of TCR expression and/or TCRγ gene rearrangement (25634749).

  • 46% are TCRβ positive (αβ T)
  • 13% are TCRγ and/or δ positive (γδ T)
  • 26% are TCR-silent type with clonal TCRγ gene rearrangement but no expression of TCRβ, γ, or δ.


Notably, the survival time of the 5 nodal lymphoma patients with γδ T-cell phenotype is within 3 months, which is inferior to those of αβ T and TCR-silent types (25634749).

See also

- EBV-associated cytotoxic T/NK-cell lymphoma
- extranasal NK/T-cell lymphoma of nasal type (ENKTL)


- T-cell Receptor (TCR) Phenotype of Nodal Epstein-Barr Virus (EBV)-positive Cytotoxic T-cell Lymphoma (CTL): A Clinicopathologic Study of 39 Cases. Kato S, Asano N, Miyata-Takata T, Takata K, Elsayed AA, Satou A, Takahashi E, Kinoshita T, Nakamura S. Am J Surg Pathol. 2015 Jan 28. PMID: 25634749