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tumor budding

Wednesday 25 February 2015

Definition: Tumor budding is a well-established adverse prognostic factor in colorectal cancer.

Images

- Recommendations for Reporting Tumor Budding in CRC based on the International Tumor Budding Consensus Conference 2016 at ESPIAP Cologne2016

By tumors

- tumor budding in colorectal adenocarcinoma (CRC)

  • Tumor budding is a well-established adverse prognostic factor in colorectal cancer.

- tumor budding in gastric adenocarcinoma (30334831)

  • High tumor budding is an independent prognostic factor in gastric adenocarcinoma, but its value is limited to the intestinal type of gastric adenocarcinoma.
  • In diffuse type gastric adenocarcinoma, the assessment of tumor budding is hardly feasible, and it does not have prognostic relevance.

- pancreatic ductal adenocarcinoma

  • Tumor Budding Is an independent adverse prognostic factor in pancreatic ductal adenocarcinoma. (25634751)
  • The assessment of budding with H&E is reliable and could be used to better risk stratify patients with pancreatic ductal adenocarcinoma. (25634751)

- esophageal adenocarcinoma

  • Tumor budding is associated with an increased risk of lymph node metastasis and poor prognosis in superficial esophageal adenocarcinoma. (24762549)

Open references

- Tumor budding is associated with an increased risk of lymph node metastasis and poor prognosis in superficial esophageal adenocarcinoma. Landau MS, Hastings SM, Foxwell TJ, Luketich JD, Nason KS, Davison JM. Mod Pathol. 2014 Dec;27(12):1578-89. doi : 10.1038/modpathol.2014.66 PMID: 24762549 (Free)

Paywall References

- Tumor Budding and Prognosis in Gastric Adenocarcinoma. Kemi N, Eskuri M, Ikäläinen J, Karttunen TJ, Kauppila JH. Am J Surg Pathol. 2018 Oct 16. doi : 10.1097/PAS.0000000000001181 PMID: 30334831

- Tumor Budding Is an Independent Adverse Prognostic Factor in Pancreatic Ductal Adenocarcinoma. O’Connor K, Li-Chang HH, Kalloger SE, Peixoto RD, Webber DL, Owen DA, Driman DK, Kirsch R, Serra S, Scudamore CH, Renouf DJ, Schaeffer DF. Am J Surg Pathol. 2015 Jan 28. PMID: 25634751