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STAT6
Tuesday 24 June 2014
IHC marker
STAT6 overexpression in solitary fibrous tumors (SFTs). (24625420)
- NAB2-STAT6 gene fusion in SFTs
- https://twitter.com/capath/status/823577425888079872
- https://twitter.com/histiocytosisX/status/861657477338804226
- https://twitter.com/ariabdullah1978/status/1589308864033615873
Pathology
STAT6 amplification
- STAT6 is amplified in a subset of dedifferentiated liposarcoma. Doyle LA, Tao D, Mariño-Enríquez A. Mod Pathol. 2014 Jan 24.
- doi : 10.1038/modpathol.2013.247 PMID: 24457460
NAB2-STAT6 gene fusion in solitary fibrous tumor (SFT)
- Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. (23313952, 23313954)
- NAB2-STAT6 gene fusion in renal solitary fibrous tumor (SFT) (26337721, 26425382, 26686340)
- NAB2
Open references
A GRIA2 and PAX8-positive renal solitary fibrous tumor with NAB2-STAT6 gene fusion. Ichiyanagi O, Ito H, Takai S, Naito S, Kato T, Nagaoka A, Yamakawa M. Diagn Pathol. 2015 Sep 4;10(1):155. doi : 10.1186/s13000-015-0386-x PMID: 26337721 (Free)
STAT6 is amplified in a subset of dedifferentiated liposarcoma. Doyle LA, Tao D, Mariño-Enríquez A. Mod Pathol. 2014 Jan 24. doi : 10.1038/modpathol.2013.247 PMID: 24457460 (Free)
Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Robinson DR, Wu YM, Kalyana-Sundaram S, Cao X, Lonigro RJ, Sung YS, Chen CL, Zhang L, Wang R, Su F, Iyer MK, Roychowdhury S, Siddiqui J, Pienta KJ, Kunju LP, Talpaz M, Mosquera JM, Singer S, Schuetze SM, Antonescu CR, Chinnaiyan AM. Nat Genet. 2013 Feb;45(2):180-5. doi : 10.1038/ng.2509 PMID: 23313952 [Free]
References
References
Analysis of NAB2-STAT6 Gene Fusion in 17 Cases of Meningeal Solitary Fibrous Tumor/Hemangiopericytoma: Review of the Literature. Yuzawa S, Nishihara H, Wang L, Tsuda M, Kimura T, Tanino M, Tanaka S. Am J Surg Pathol. 2016 Feb 26. PMID: 26927892
NAB2-STAT6 Gene Fusion in Meningeal Hemangiopericytoma and Solitary Fibrous Tumor. Fritchie KJ, Jin L, Rubin BP, Burger PC, Jenkins SM, Barthelmeß S, Moskalev EA, Haller F, Oliveira AM, Giannini C. J Neuropathol Exp Neurol. 2016 Feb 16. pii: nlv026. PMID: 26883114
STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors. Yoshida A, Tsuta K, Ohno M, Yoshida M, Narita Y, Kawai A, Asamura H, Kushima R.
Am J Surg Pathol. 2014 Apr;38(4):552-9. doi : 10.1097/PAS.0000000000000137 PMID: 24625420
