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benign Brenner tumor

Thursday 25 July 2013

benign Brenner tumor of the ovary; ovarian benign Brenner tumor


Definition: Brenner tumor is a tumor of urothelial (transitional epithelium) like cells. It can be benign, borderline, or malignant.

The tumor contains nests of urothelial type cells with distinct outlines, nuclei with longitudinal grooves (“coffee bean”) and a dense fibroblastic stroma. This is consistent with benign Brenner tumor. Brenner tumor can also be borderline or malignant depending on the cytologic morphology and behavior.


- Benign Brenner tumor of the ovary : Macroscopy : Usually unilateral, gritty, firm

- Benign Brenner tumor of the ovary : Microscopy


- The Brenner tumors are composed of solid and cystic nests of epithelium resembling transitional epithelium in a dense fibroblastic stroma.
- The transitional epithelial cells have sharply defined outlines, oval nuclei with longitudinal grooves, and small or inconspicuous nucleoli.
- Nests of transitional cells with pale cytoplasm scattered in a dense stroma.
- The stromal component usually resembles an ovarian fibroma and may contain luteinized cells.
- Estrogen secretion by stromal cells may occasionally result in endocrine manifestations.
- Irregular nests of benign transitional (urothelial) cells are scattered in dense hyalinized stroma in this benign Brenner tumor.
- Brenner tumor may have small or large cysts. Often, these cysts are lined by mucinous epithelium beneath which are transitional epithelium-type cells.

See also

- transitionnal cell tumors
- ovarian tumors