myxoid soft tissue tumors

Definition: Myxoid tumours of soft tissue encompass a heterogeneous group of lesions characterized by a marked abundance of extracellular mucoid (myxoid) matrix.

Images

 Circumscribed myxoid lesion of finger by Ed Euthman

 Ossifying fibromyxoid tumour, male, 60yo, right thigh

• https://twitter.com/SkinPathology/status/782876199387209728

Examples

Benign	Locally aggressive	Malignant
dermal myxoma	juxta-articular myxoma	myxofibrosarcoma
superficial angiomyxoma	aggressive angiomyxoma	low-grade fibromyxoid sarcoma
Ganglion	( low-grade myxofibrosarcoma )	myxoid liposarcoma
myxoid nodular fasciitis	(Atypical OFMT)	extraskeletal myxoid chondrosarcoma
myxoid neurofibroma		myxoid leiomyosarcoma
myxolipoma		myxoid MPNST
dermal nerve sheath myxoma		myxoid DFSP
intramuscular myxoma		myxopapillary ependymoma
ossifying fibromyxoid tumour (OFMT)

Differential diagnosis

 myxofibrosarcoma
 myxoid fibroblastic sarcoma
 intramuscular myxoma
 myxoid liposarcoma

Diagnostic approach

 Size
 Level
 Architecture
 Vessels
 Cellularity
 Atypia
 Immunohistochemistry and/or molecular pathology

level

Dermal	dermal nerve sheath myxoma	superficiel angiomyxoma	digital myxoma	digital fibromyxoma
Subcutaneous	nodular fasciitis, myxoid type	myxofibrosarcoma	ossifying fibromyxoid tumor	(acral) myxoinflammatory fIbroblastic sarcoma		Intra-muscular	intramuscular	low-grade fibromyxoid sarcoma	myxoid liposarcoma	deep angiomyxoma

Images

 superficial acral fibromyxoma

• Image : https://twitter.com/LinskeyKaty/status/733018339065401344

Links

 http://www.pathologydiagnostics.org/userfiles/Myxoid_tumours.pdf

See also

 myxoid tumors
 soft tissue tumors

References

 Myxoid tumours of soft tissue. Graadt van Roggen JF, Hogendoorn PC, Fletcher CD. Histopathology. 1999 Oct;35(4):291-312. PMID: 10564384 http://www.pathologydiagnostics.org/userfiles/Myxoid_tumours.pdf