HBME1

PO

HBME1 is a marker of mesothelial cells, named after laboratory of Dr. Hector Battifora and MEsothelioma.

Expression in tumors

 mesothelioma
 thyroid carcinomas

• In a study, 87.2% of adenomatous goiter and 72.6% of follicular adenoma were negative. 84.6% of follicular carcinoma and 97.2% of papillary carcinoma were positive. All anaplastic and medullary carcinoma tested were negative. (12803237)

Open References

 The Immunocytochemistry Is a Valuable Tool in the Diagnosis of Papillary Thyroid Cancer in FNA’s Using Liquid-Based Cytology. Pazaitou-Panayiotou K, Mygdakos N, Boglou K, Kiziridou A, Chrisoulidou A, Destouni C. J Oncol. 2010;2010:963926. PMID: 21052476 (Free)

 Solid cell nests, papillary thyroid microcarcinoma, and HBME1. Seethala RR, Chiosea SI. Am J Clin Pathol. 2010 Jul;134(1):169-70. PMID: 20551283 (Free)

 Absence of the BRAF mutation in HBME1+ and CK19+ atypical cell clusters in Hashimoto thyroiditis: supportive evidence against preneoplastic change. Nasr MR, Mukhopadhyay S, Zhang S, Katzenstein AL. Am J Clin Pathol. 2009 Dec;132(6):906-12. PMID: 19926583 [Free]

 Differential expression of galectin-3, CK19, HBME1, and Ret oncoprotein in the diagnosis of thyroid neoplasms by fine needle aspiration biopsy. Saleh HA, Feng J, Tabassum F, Al-Zohaili O, Husain M, Giorgadze T. Cytojournal. 2009 Sep 18;6:18. PMID: #19826479 [Free]

 Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. Scognamiglio T, Hyjek E, Kao J, Chen YT. Am J Clin Pathol. 2006 Nov;126(5):700-8. PMID: 17050067 [Free]

 Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: Utility of HBME1 combined with CK19 immunostaining. Nasr MR, Mukhopadhyay S, Zhang S, Katzenstein AL. Mod Pathol. 2006 Dec;19(12):1631-7. PMID: 16998461 [Free]

 Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Prasad ML, Pellegata NS, Huang Y, Nagaraja HN, de la Chapelle A, Kloos RT. Mod Pathol. 2005 Jan;18(1):48-57. PMID: 15272279 [Free]

 HBME-1 immunostaining in thyroid tumors especially in follicular neoplasm.
Mase T, Funahashi H, Koshikawa T, Imai T, Nara Y, Tanaka Y, Nakao A. Endocr J. 2003 Apr;50(2):173-7. PMID: 12803237 [Free]

Reference

 Immunocytochemistry with cytokeratin 19 and anti-human mesothelial cell antibody (HBME1) increases the diagnostic accuracy of thyroid fine-needle aspirations: preliminary report of 150 liquid-based fine-needle aspirations with histological control. Cochand-Priollet B, Dahan H, Laloi-Michelin M, Polivka M, Saada M, Herman P, Guillausseau PJ, Hamzi L, Poté N, Sarfati E, Wassef M, Combe H, Raulic-Raimond D, Chedin P, Medeau V, Casanova D, Kania R. Thyroid. 2011 Oct;21(10):1067-73. PMID: 21875347