ERG/P63 double immunohistochemical staining

TMPRSS2:ERG gene rearrangement was found to be highly specific for and detected in approximately 50% of prostate cancer.

The P63/ERG double immunostain combines the high sensitivity of P63 and the high specificity of ERG and may be potentially useful in the work-up of difficult prostate biopsies. (21623182)

The high specificity of ERG for the presence of cancer may have important implications for prostate biopsy interpretation and needs to be further validated in larger prospective studies. (21623182)

References

 The utility of ERG/P63 double immunohistochemical staining in the diagnosis of limited cancer in prostate needle biopsies. Yaskiv O, Zhang X, Simmerman K, Daly T, He H, Falzarano S, Chen L, Magi-Galluzzi C, Zhou M. Am J Surg Pathol. 2011 Jul;35(7):1062-8. PMID: 21623182