Home > G. Tumoral pathology > immunophenotype of mature B-cell lymphomas
immunophenotype of mature B-cell lymphomas
Friday 10 August 2012
small lymphocytic lymphoma
- strong expression: IgM/IgD, CD20, CD22, CD5, CD19, CD79a, CD23, CD43
- weak expression: CD11c
- negative: CD10
- usually negative: FMC7, CD79b, CyD1
- possible atypical immunophenotype: CD5-, CD23-, FMC7+, CD11c+
B-cell prolymphocytic leukemia
- strong expression: IgM+/IgD+, CD19, CD20, CD22, CD79a, CD79b, FMC7
- possible expression: CD5 (20-30%), CD23 (10-20%), ZAP-70 (57%), CD38 (46%)
splenic marginal zone lymphoma
- strong expression: sIgM, CD20, CD79a,
- possible expression: IgD
- usually negative: CD5
- negative: CD5, CD10, BCL6, CD23, CD43, annexin A1, CyD1
hairy cell leukemia
- strong expression: CD20, CD22, CD11c
- expression: CD103, CD25, CD123, T-bet, Annexin A1 (ANXA1), DBA 44 (CD72), FMC-7 and CyD1
- usuallly negative: CD5 and CD10
