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mammary Paget disease
Tuesday 3 July 2012
Paget disease of the breast
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Definition: Mammary Paget disease (MPD) is considered an intraepidermal manifestation of an underlying mammary carcinoma.
In contrast to extramammary Paget disease, invasion of mammary Paget cells into the dermis (invMPD) has very rarely been reported (22895267).
Images
https://twitter.com/kis_lorand/status/1386723059000881152
https://twitter.com/bels1992/status/1432354539362045953
Synopsis
Single cells or clusters of cells spread throughout the epidermis
Cells have abundant pale cytoplasm, large irregular nuclei with prominent nucleoli
Underlying dermis may have chronic inflammation
Epidermis with hyperkeratosis and possibly ulceration
Florid cases can show gland formation
Paget cells may phagocytose melanin, mimicking melanocytes
Underlying carcinoma is most commonly high grade invasive carcinoma of no special type (NST; 53 - 64%) or DCIS (24 - 43%) (Histopathology 2020;77:181)
Digital cases
JRC:5395 : Mammary Paget disease.
JRC:5397 : Mammary Paget disease.
JRC:5398 : Mammary Paget disease.
JRC:5399 : Mammary Paget disease.
JRC:5400 : Mammary Paget disease.
See also
mammary tumors
References
Invasive paget disease of the breast: clinicopathologic study of an underrecognized entity in the breast. Duan X, Sneige N, Gullett AE, Prieto VG, Resetkova E, Andino LM, Wu Y, Gilcrease MZ, Bedrosian I, Dawood S, Arun B, Albarracin CT. Am J Surg Pathol. 2012 Sep;36(9):1353-8. PMID: 22895267
