GCET2

Pathology

 diffuse large B-cell lymphoma (DLBCL)

• Diffuse large B-cell lymphomacan be subclassified into at least two molecular subgroups by gene expression profiling: germinal center B-cell like and activated B-cell like diffuse large B-cell lymphoma.
• Several immunohistological algorithms have been proposed as surrogates to gene expression profiling at the level of protein expression, but their reliability has been an issue of controversy.
• Furthermore, the proportion of misclassified cases of germinal center B-cell subgroup by immunohistochemistry, in all reported algorithms, is higher compared with germinal center B-cell cases defined by gene expression profiling.
• HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma.

References

 The contribution of HGAL/GCET2 in immunohistological algorithms: a comparative study in 424 cases of nodal diffuse large B-cell lymphoma. Gualco G, Bacchi LM, Domeny-Duarte P, Natkunam Y, Bacchi CE. Mod Pathol. 2012 Jun 29. PMID: 22743653