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RB/E2F pathway

Thursday 20 November 2003

Functions

- The Rb/E2F pathway is critical in regulating the initiation of DNA replication.

- The pathway controls the activity of the retinoblastoma tumor suppressor protein (RB), which in turn regulates the E2F transcription factor.

- The Rb/E2F pathway is critical in regulating the initiation of DNA replication.

- The control of the Rb/E2F pathway is disrupted in virtually all human cancers.

References

- Calzone L, Gelay A, Zinovyev A, Radvanyl F, Barillot E. A comprehensive modular map of molecular interactions in RB/E2F pathway. Mol Syst Biol. 2008;4:173. PMID: 18319725

Reviews

- DeGregori J, Johnson DG. Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med. 2006 Nov;6(7):739-48. PMID: 17100600

- Johnson DG, Degregori J. Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context. Curr Mol Med. 2006 Nov;6(7):731-8. PMID: 17100599

- Korenjak M, Brehm A. E2F-Rb complexes regulating transcription of genes important for differentiation and development. Curr Opin Genet Dev. 2005 Oct;15(5):520-7. PMID: 16081278

- Nevins JR. The Rb/E2F pathway and cancer. Hum Mol Genet. 2001 Apr;10(7):699-703. PMID: 11257102