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Friday 17 June 2011


Definition : Trichoepithelioma is a benign neoplasm that shares both clinical and histological features with basal cell carcinoma.


- Trichoepithelioma

- stroma-stroma retraction in trichoepithelioma

- small trichoepithelioma

- desmoplastic trichoepithelioma : cords/nests basaloid cells, sclerotic stroma, horn cysts with keratin

- Trichoepithelioma CK20+ Merkel cells (usually absent in BCC)

- Stromal hyaline droplets in a trichoepithelioma


- multilobular basaloid tumor
- palisaded nuclei
- fibrocellular stroma
- hair follicle tumor with basaloid cells in nests surrounded by dense fibrous stroma and spindle cells
- mucin pools may be present within basaloid nests
- lack of clefting distinguishes from basal cell carcinoma

Differential diagnosis

- basal cell carcinoma (BCC)

Digital cases

- UI:910 - Trichoepithelioma

See also

- cutaenous tumors


- Diagnostic utility of immunohistochemistry in distinguishing trichoepithelioma and basal cell carcinoma: evaluation using tissue microarray samples. Tebcherani AJ, de Andrade HF Jr, Sotto MN. Mod Pathol. 2012 Jun 8. PMID: 22684216